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1

Thrombin generation for the control of heparin treatment, comparison with the activated partial thromboplastin time

R. Al Dieri, S. Alban, S. Béguin, H. Coenraad Hemker

Journal:

Journal of Thrombosis and Haemostasis

Year:

2004

Language:

english

File:

PDF, 234 KB

english, 2004

2

Low Molecular Weight Activated Protein C Inhibitors as a Potential Treatment for Hemophilic Disorders

De Nanteuil, Guillaume, Gloanec, Philippe, Béguin, Suzette, Giesen, Peter L. A., Hemker, H. Coenraad, Mennecier, Philippe, Rupin, Alain, Verbeuren, Tony J.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 88 KB

english, 2006

3

Measurement of thrombin generation intra-operatively and its association with bleeding tendency after cardiac surgery

Bosch, Yvonne P.J., Al Dieri, Raed, ten Cate, Hugo, Nelemans, Patty J., Bloemen, Saartje, de Laat, Bas, Hemker, Coenraad, Weerwind, Patrick W., Maessen, Jos G., Mochtar, Baheramsjah

Journal:

Thrombosis Research

Year:

2014

Language:

english

File:

PDF, 451 KB

english, 2014

4

Critical perceptions on problem-based learning

COENRAAD HEMKER, H.

Journal:

European Review

Year:

2001

Language:

english

File:

PDF, 23 KB

english, 2001

5

Analysis of thrombin generation in plasma

Han Kessels, George Willems, H.Coenraad Hemker

Journal:

Computers in Biology and Medicine

Year:

1994

Language:

english

File:

PDF, 974 KB

english, 1994

6

A convenient synthesis of amino acid p-nitroanilides; synthons in the synthesis of protease substrates

Dirk T.S. Rijkers, Hans P.H.M. Adams, H. Coenraad Hemker, Godefridus I. Tesser

Journal:

Year:

1995

Language:

english

File:

PDF, 1.03 MB

english, 1995

7

Acquired APC resistance and oral contraceptives: differences between two functional tests

Joyce Curvers, M. Christella L. G. D. Thomassen, Gerry A. F. Nicolaes, Rene Van Oerle, Karly Hamulyak, H. Coenraad HEMKER, Guido Tans, Jan Rosing

Journal:

British Journal of Haematology

Year:

1999

Language:

english

File:

PDF, 144 KB

english, 1999

8

Critical Perceptions on Problem-based Learning

H. Coenraad Hemker

Journal:

Advances in Health Sciences Education

Year:

1998

Language:

english

File:

PDF, 33 KB

english, 1998

9

Fluorogenic Peptide-Based Substrates for Monitoring Thrombin Activity

Dr. Sander S. van Berkel, Bas van der Lee, Dr. Floris L. van Delft, Dr. Rob Wagenvoord, Prof. Dr. H. Coenraad Hemker, Prof. Dr. Floris P. J. T. Rutjes

Journal:

Year:

2012

Language:

english

File:

PDF, 789 KB

english, 2012

10

Cover Picture: Fluorogenic Peptide-Based Substrates for Monitoring Thrombin Activity (ChemMedChem 4/2012)

Dr. Sander S. van Berkel, Bas van der Lee, Dr. Floris L. van Delft, Dr. Rob Wagenvoord, Prof. Dr. H. Coenraad Hemker, Prof. Dr. Floris P. J. T. Rutjes

Journal:

Year:

2012

Language:

english

File:

PDF, 746 KB

english, 2012

11

Vitamin K-dependent carboxylase: the carboxylation of exogenous substrates in different systems

Marian A.G. de Boer-van den Berg, Magda M.W. Ulrich, H.Coenraad Hemker, Berry A.M. Soute, Cees Vermeer

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1985

Language:

english

File:

PDF, 353 KB

english, 1985

12

Draculin, the anticoagulant factor in vampire bat saliva, is a tight-binding, noncompetitive inhibitor of activated factor X

Ana Z. Fernandez, Alfonso Tablante, Suzette Beguı́n, H.Coenraad Hemker, Rafael Apitz-Castro

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1999

Language:

english

File:

PDF, 277 KB

english, 1999

13

The placental transport of [3H] vitamin K1 in rats

Karly Hamulyák, Marian A. G De Boervanden Berg, Henk H. W. Thijssen, H. Coenraad Hemker, Cees Vermeer

Journal:

British Journal of Haematology

Year:

1987

Language:

english

File:

PDF, 319 KB

english, 1987

14

Inhibition of phospholipid and platelet-dependent prothrombinase activity in the plasma of patients with lupus anticoagulants

Monica Galli, Suzette Béguin, Theo Lindhout, Coenraad H. Hemker

Journal:

British Journal of Haematology

Year:

1989

Language:

english

File:

PDF, 625 KB

english, 1989

15

Ratios of anti-factor Xa to antithrombin activities of heparins as determined in recalcified human plasma

Pieter Schoen, Theo Lindhoux, H. Coenraad Hemker

Journal:

British Journal of Haematology

Year:

1992

Language:

english

File:

PDF, 776 KB

english, 1992

16

Synthesis of peptide p-nitroanilides mimicking fibrinogen- and hirudin-binding to thrombin Design of slow reacting thrombin substrates

DIRK T.S. RIJKERS, H. COENRAAD HEMKER, GODEFRIDUS I. TESSER

Journal:

Chemical Biology & Drug Design

Year:

1996

Language:

english

File:

PDF, 1.16 MB

english, 1996

17

Lipid Phase Transitions and Procoagulant Activity

Guido TANS, Henk van ZUTPHEN, Paul COMFURIUS, H. Coenraad HEMKER, Robert F. A. ZWAAL

Journal:

Year:

1979

Language:

english

File:

PDF, 826 KB

english, 1979

18

Generation of Prothrombin-Converting Activity and the Exposure of Phosphatidylserine at the Outer Surface of Platelets

Edouard M. BEVERS, Paul COMFURIUS, Jan L. M. L. VAN RIJN, H. Coenraad HEMKER,

Journal:

Year:

1982

Language:

english

File:

PDF, 944 KB

english, 1982

19

Isolation and partial purification of a novel anticoagulant from arteries of human umbilical cord

Chris P. M. REUTELINGSPERGER, Gerard HORNSTRA, H. Coenraad HEMKER

Journal:

Year:

1985

Language:

english

File:

PDF, 550 KB

english, 1985

20

Kinetics of thrombin-induced release and activation of platelet factor V

Dominique BARUCH, H. Coenraad HEMKER, Theo LINDHOUT

Journal:

Year:

1986

Language:

english

File:

PDF, 573 KB

english, 1986

21

The effect of factor Va on lipid dynamics in mixed phospholipid vesicles as detected by steady-state and time-resolved fluorescence depolarization of diphenylhexatriene

Piet van de WARRT, Antonie J. W. G. VISSER, H. Coenraad HEMKER, Theo LINDHOUT

Journal:

Year:

1987

Language:

english

File:

PDF, 735 KB

english, 1987

22

Purification and characterization of a novel protein from bovine aorta that inhibits coagulation : Inhibition of the phospholipid-dependent factor-Xa -catalyzed prothrombin activation, through a high-affinity binding of the anticoagulant to the phospholipids

Chris P. M. REUTELINGSPERGER, Jos M. M. KOP, Gerard HORNSTRA, H. Coenraad HEMKER

Journal:

Year:

1988

Language:

english

File:

PDF, 870 KB

english, 1988

23

The effect of phospholipids, calcium ions and protein S on rate constants of human factor Va inactivation by activated human protein C

Harry M. BAKKER, Guido TANS, Truus JANSSEN-CLAESSEN, M. Christella L. G. D. THOMASSEN, H. Coenraad HEMKER, John H. GRIFFIN, Jan ROSING

Journal:

Year:

1992

Language:

english

File:

PDF, 869 KB

english, 1992

24

The Ca2+-Mobilizing Potency of α-Thrombin and Thrombin-Receptor-Activating Peptide on Human Platelets : Concentration and Time Effects of Thrombin-Induced Ca2+ Signaling

Johan W. M. Heemskerk, Marion A. H. Feijge, Lidewij Henneman, Jan Rosing, H. Coenraad Hemker

Journal:

Year:

1997

Language:

english

File:

PDF, 956 KB

english, 1997

25

Monitoring of unbound protein in vesicle suspensions with off-null ellipsometry

Peter L.A. Giesen, George M. Willems, H.Coenraad Hemker, Marc C.A. Stuart, Wim Th. Hermens

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1993

Language:

english

File:

PDF, 585 KB

english, 1993

26

Production of thrombin as a probe for mixing of phospholipids in membranes on solid supports

Peter L.A. Giesen, H.Coenraad Hemker, Wim Th. Hermens

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1995

Language:

english

File:

PDF, 685 KB

english, 1995

27

Interindividual variation in relationships between plasma heparin concentration and the results of five heparin assays

Janjaap van Putten, Marjo van de Ruit, Marlene Beunis, H.Coenraad Hemker

Journal:

Clinica Chimica Acta

Year:

1982

Language:

english

File:

PDF, 703 KB

english, 1982

28

Phenotyping the haemostatic system by thrombography—potential for the estimation of thrombotic risk

Véronique Regnault, H.Coenraad Hemker, Denis Wahl, Thomas Lecompte

Journal:

Thrombosis Research

Year:

2004

Language:

english

File:

PDF, 597 KB

english, 2004

29

Linear diffusion of thrombin and factor Xa along the heparin molecule explains the effects of extended heparin chain lengths

Rob Wagenvoord, Raed Al Dieri, Gijs van Dedem, Suzette Béguin, H. Coenraad Hemker

Journal:

Thrombosis Research

Year:

2008

Language:

english

File:

PDF, 450 KB

english, 2008

30

Monitoring platelet dependent thrombin generation in mice

Yesim Dargaud, Henri M.H. Spronk, Peter Leenders, H. Coenraad Hemker, Hugo Ten Cate

Journal:

Thrombosis Research

Year:

2010

Language:

english

File:

PDF, 673 KB

english, 2010

31

Evaluation of the procoagulant activity in the plasma of cancer patients using a thrombin generation assay

France Debaugnies, Marie-Agnès Azerad, Denis Noubouossié, Laurence Rozen, H. Coenraad Hemker, F. Corazza, André Efira, Anne Demulder

Journal:

Thrombosis Research

Year:

2010

Language:

english

File:

PDF, 350 KB

english, 2010

32

No Effect of Ethanol Intake on Thrombin Generation Parameters

Saartje Bloemen, Marlien Pieters, H. Coenraad Hemker, Raed Al Dieri

Journal:

Thrombosis Research

Year:

2012

Language:

english

File:

PDF, 252 KB

english, 2012

33

Prevention of the Influence of Fibrin and α2-Macroglobulin in the Continuous Measurement of the Thrombin Potential: Implications for an Endpoint Determination of the Optical Density

Dirk T.S Rijkers, Simone J.H Wielders, Suzette Béguin, H.Coenraad Hemker

Journal:

Thrombosis Research

Year:

1998

Language:

english

File:

PDF, 162 KB

english, 1998

34

Purification and Characterization of Multisquamase, the Prothrombin Activator Present in Echis Multisquamatus Venom

Ramona J Petrovan, José W.P Govers-Riemslag, Götz Nowak, H.Coenraad Hemker, Jan Rosing, Guido Tans

Journal:

Thrombosis Research

Year:

1997

Language:

english

File:

PDF, 524 KB

english, 1997

35

Heterogeneity in microparticle formation and exposure of anionic phospholipids at the plasma membrane of single adherent platelets

Jacob J Briedé, Johan W.M Heemskerk, H.Coenraad Hemker, Theo Lindhout

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

1999

Language:

english

File:

PDF, 2.22 MB

english, 1999

36

Thrombin generation: What have we learned?

Al Dieri, Raed, de Laat, Bas, Hemker, H. Coenraad

Journal:

Year:

2012

Language:

english

File:

PDF, 380 KB

english, 2012

37

Clotting factors secreted by monocytes and macrophages: Analytical considerations

Maria C.E. van Dam-Mieras, Annemarie D. Muller, Wijgert A. van Deijk, H.Coenraad Hemker

Journal:

Thrombosis Research

Year:

1985

Language:

english

File:

PDF, 778 KB

english, 1985

38

Effect of heparin and low molecular weight heparins on thrombin-induced blood platelet activation in the absence of antithrombin III

Dominique Baruch, Jo Franssen, H.Coenraad Hemker, Theo Lindhout

Journal:

Thrombosis Research

Year:

1985

Language:

english

File:

PDF, 897 KB

english, 1985

39

Data management in Thrombin Generation

Hemker, H. Coenraad, Kremers, R.

Journal:

Thrombosis Research

Year:

2013

Language:

english

File:

PDF, 1.13 MB

english, 2013

40

Adsorption Kinetics of Protein Mixtures A Tentative Explanation of the Vroman Effect

PETER A. CUYPERS, GEORGE M. WILLEMS, H. COENRAAD HEMKER, WIM TH. HERMENS

Journal:

Annals of the New York Academy of Sciences

Year:

1987

Language:

english

File:

PDF, 404 KB

english, 1987

41

Surface exclusion and molecular mobility may explain Vroman effects in protein adsorption

Willems, George M., Th. Hermens, Wim, Coenraad Hemker, H.

Journal:

Journal of Biomaterials Science Polymer Edition

Year:

1991

Language:

english

File:

PDF, 271 KB

english, 1991

42

The technique of measuring thrombin generation with fluorogenic substrates: 1. Necessity of adequate calibration

De Smedt, Erik, Al Dieri, Raed, Spronk, Henri M. H., Hamulyak, Karli, ten Cate, Hugo, Hemker, H. Coenraad

Journal:

Thrombosis and Haemostasis

Year:

2008

Language:

english

File:

PDF, 379 KB

english, 2008

43

Factor Va-factor Xa interaction. Effects of phospholipid vesicles of varying composition

Lindhout, Theo, Govers-Riemslag, Jose W. P., Van de Waart, Piet, Coenraad Hemker, H., Rosing, Jan

Journal:

Year:

1982

Language:

english

File:

PDF, 1.94 MB

english, 1982

44

Calibrated Automated Thrombin Generation Measurement in Clotting Plasma

Hemker, H. Coenraad, Giesen, Peter, Al Dieri, Raed, Regnault, V&eacute, ronique, de Smedt, Eric, Wagenvoord, Rob, Lecompte, Thomas, B&eacute, guin, Suzette

Journal:

Pathophysiology of Haemostasis and Thrombosis

Year:

2003

Language:

english

File:

PDF, 158 KB

english, 2003

45

Free factor Xa is on the main pathway of thrombin generation in clotting plasma

Hemker, H.Coenraad, Choay, Jean, Beguin, Suzette

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

1989

Language:

english

File:

PDF, 158 KB

english, 1989

46

Inhibition of Prothrombinase at Macroscopic Lipid Membranes: Competition between Antithrombin and Prothrombin

Billy, Didier, Speijer, Han, Lindhout, Theo, Hemker, H. Coenraad, Willems, George M.

Journal:

Year:

1995

Language:

english

File:

PDF, 748 KB

english, 1995

47

Human Factor Va 1 and Factor Va 2 : Properties in the Procoagulant and Anticoagulant Pathways †

Hoekema, Lico, Nicolaes, Gerry A. F., Hemker, H. Coenraad, Tans, Guido, Rosing, Jan

Journal:

Year:

1997

Language:

english

File:

PDF, 220 KB

english, 1997

48

Inhibition of factor XIa by antithrombin III

Soons, Hans, Janssen-Claessen, Truus, Tans, Guido, Hemker, H. Coenraad

Journal:

Year:

1987

Language:

english

File:

PDF, 1.60 MB

english, 1987

49

Autocatalytic Peptide Bond Cleavages in Prothrombin and Meizothrombin †

Petrovan, Ramona J., Govers-Riemslag, José W. P., Nowak, Götz, Hemker, H. Coenraad, Tans, Guido, Rosing, Jan

Journal:

Year:

1998

Language:

english

File:

PDF, 77 KB

english, 1998

50

Interaction of bovine blood clotting factor Va and its subunits with phospholipid vesicles

Van de Waart, Piet, Bruls, Harry, Hemker, H. Coenraad, Lindhout, Theo

Journal:

Year:

1983

Language:

english

File:

PDF, 791 KB

english, 1983